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Tian-Le Xu

 
 

Dr. Tian-Le Xu is chair of the Department of Anatomy, Histology and Embryology, and head of Laboratory of Neuronal Signaling at Shanghai Jiao Tong University School of Medicine. His current research focuses on neuronal signaling and related neural disorders with an emphasize on the role of acid-sensing ion channels in these processes. He is serving as editorial board member for the following journals: Molecular Pain, ACS Chemical Neuroscience, Frontiers in Pharmacology of Ion Channel and Channelopathies, Neuroscience Bulletin and Journal of Neurogenetics.

 
   
 

Research Interests

 
 
All brain functions depend on signal processing within and between neuronal cells. Understanding neuronal signaling is fundamental to determining how neurons communicate, integrate and store information. Furthermore, aberrant neuronal signaling is closely associated with neural dysfunctions and major brain disorders. Signaling proteins, in particular, neuronal membrane ion channels and receptors can therefore be therapeutic targets for neural diseases. My colleagues and I are interested in the regulation of neuronal signaling by ion channels and receptors with an emphasize on the role of acid-sensing ion channels (ASICs) in these processes.
 
   
 

Lab News

 
  2017-03-04 Academic activity - Annual review meeting of major project supported by State Key Development Program for Basic Research of China (973)
Photo1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27
 
  2016-12-16 Academic activity - Prof. Guo-Hui Su, academician of Chinese Academy of Sciences (CAS),dean of Guangdong-Hong Kong-Macao Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou, visits our college. Poster News Photo  
  2016-12-08 Paper published - Congratulations to Wei-Guang Li, Ming-Gang Liu, Shi-Ning Deng, et al!
Li WG#, Liu MG#, Deng S#, Liu YM, Shang L, Ding J, Hsu TT, Jiang Q, Li Y, Li F*, Zhu MX*, Xu TL* (2016) ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion. Nature Communications, 7: 13770.
 
  2016-12-07 Academic activity - Dr. Yi-Zhi Wang from the Ken and Ruth Davee Department of Neurology, Northwestern University (former students of our lab) visits our lab.  
  2016-11-23 Academic activity - SJTU-ZJU-STU Joint Symposium for Neuroscience was held in our department!Congratulations to our lab members for their best performance! Poster  
  2016-11-13 Academic activity - Dr. Qin Hu attended in The 1st Gusu Translational Stroke Research Summit & the 4th International Symposium on Tolerance and Conditioning: "30 Years of Science and Hope" in Soochow. About Meeting Photo  
  2016-10-28 Academic activity - Lab Members attended Annual Meeting of "Neural Circuit Basis of Emotion and Memory" (Supported by Major Research Plan of the National Natural Science Foundation of China), 2016 in Shenzhen, Guangdong. About Meeting  
  2016-10-25 Happy Hour - Congratulations to Jing-Jing Wang on Ph.D. graduation!Photo1 2 3  
  2016-09-25 Academic activity - Dr.Wei-Guang Li attended 2016 International Conference of Physiological Sciences (ICPS2016) in Peking, and gave a scientific presentation named "ASIC1a regulates insular LTD and is required for extinction of CTA". About Meeting Photo  
  2016-09-10 Happy Hour - Happy Teacher's Day to Prof. Xu and all the young teachers in our lab! Lab Photo  
  2016-09-09 Academic activity - Ivana Savic, Ph.D. student from Department of Physiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel, visited our lab and colaborated with us on the NSFC-ISF project. Photo1 2 3 4  
  2016-09-07 Academic activity - Congratulations to Yan-Jiao Wu, Fan Liu, Xing-Lei Song and Xin-Yu Su!They winned Best Presentors on their Annual Reports of the Neuroscience Division, Shanghai Jiao Tong University School of Medicine this year!Photo1 2 3 4 5 6 7 8 9 10 11  
  2016-07-25 Academic activity - Hu-Song Li attented Symposium for Chinese Neuroscientists Worldwide 2016 (SCNW) in Hefei, Anhui. About Meeting Photo  
  2016-06-24 Academic activity - Dr. Qin Hu attended 2nd Annual Scientific Session of Chinese Stroke Association (TISC 2016) in Beijing. About Meeting  
  2016-06-08 Academic activity - Dr. Wen Zhang (former students of our lab) from National Institute on Drug Abuse Intramural Research Program, National Institutes of Health (NIH), USA visits our college. Poster  
  2016-05-27 Academic activity - Lab members attended ITNCR (Innovative Technologies on Neural Circuit Research) Meeting (virus tracing, imaging & function), 2016 in Wuhan, Hubei. About Meeting Photo  
  2016-05-21 Academic activity - Yanjiao Wu attended Cold Spring Habor Asia(CSHA) Conference: Development, Function & Disease of Neural Circuits, 2016 in Soochow, Jiangsu. About Meeting  
  2016-05-14 Happy Hour - Congratulations to Bai-Hui He and our RBL 2014 team!They winned Award for Outstanding Experimental Talents in Practical Innovation Forum of Fudan University, School of Medicine. Photos1 2 3 4  
  2016-05-09 Happy Hour - Congratulations to Yi-Ming Jiang on Ph.D. graduation!Photo1 2  
  2016-04-30 Academic activity - Prof. Xu and Dr. Qin Hu attended Young Scholars Forum of Ion Channel Research, 2016 in Hangzhou, Zhejiang. About Meeting Photo1 2  
  2016-04-26 Academic activity - Dr.Shujia Zhu from Vollum Institute, Oregon Health & Science University,USA vistis our college. Poster  
  2016-04-23 Academic activity - Lab members attended the The 4th International Symposium on Synaptic Transmission and Plasticity (2016 ISSTP) in Nanchang, Jiangxi.about ISSTP 1 2  
  2016-04-16 Happy Hour - Congratulations to our RBL 2014 team (Research-Based Learning) !They winned Award for Outstanding Experimental Achievement in Innovative Practices Competition of Shanghai Jiao Tong University, School of Medicine. Photo1 2 3 News1 2  
  2016-03-22 Paper accpeted - Congratulations to Ming-Gang Liu, Hu-Song Li, et al!
Liu MG, Li HS, Li WG, Wu YJ, Deng SN, Huang C, Maximyuk O, Sukach V, Krishtal O, Zhu MX*, Xu TL*. Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms. Scientific Reports. 6:23350.
 
  2016-03-21 Academic activity - Dr. Qian Li from Department of Cell Biology, Havard Medical School, visits our college. Poster  
  2016-03-14 Academic activity - Prof. John H. Zhang from Departments of Anesthesiology, Neurosurgery, Neurology and Physiology, Loma Linda University School of Medicine, visits our college. Zhang Lab Poster Photo1 2 3  
  2016-03-10 Academic activity - Prof. Yuanxiang Tao from Department of Anesthesiology, Rutgers New Jersey Meidcal School, visits our college. Tao Lab Photo News  
  2016-03-02 Happy Hour - Congratulations to Dr. Wei-Guang Li!He winned support for Support Program for Young Talents (2015-2017), China Association for Science and Technology!News1 2  
  2016-02-05 Happy Hour - Wish everyone happy in the Chinese lunar year of monkey!  
  2015-12-08 Happy Hour - Congratulations to Hu-Song Li! He winned the 1st Prizes for both the Best Poster and Best Question in Annual Xinyu Cup of Shanghai Jiaotong University School of Medicine!!  
  2015-11-26 Academic activity - Prof. Krishtal Oleg, HHMI, Director & Head of the Department for Cellular Membranology of the Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine,visits our college. Oleg Lab Photo1 2 3 4 5  
  2015-11-23 Happy Hour - Congratulations to Dr. Wei-Guang Li!He winned Support for Outstanding Young Teachers in School of Medicine, SJTU!  
  2015-11-20 Academic activity - Lab members attended the 14th Chinese Biophysics Congress in Kunming, Yunnan About CBC  
  2015-11-13 Academic activity - Lab members attended the CSHA Conference: Targeting Cell Death Mechanisms for the Treatment of Human Diseases in Suzhou, Jiangsu. About CSHA Photo  
  2015-11-13 Academic activity - Dr. Xu attened EMNC2015 meeting with our lab members in Beijing. About ENMC Photo1 2 3  
  2015-11-10 Academic activity - Lab members attended the 6th Asian Pain Symposium (APS 2015) in Suzhou, Jiangsu.(APS 2015) About APS Photo  
  2015-11-04 Academic activity - Prof. Zhigang Xiong from Department of Neurobiology, Mourehouse School of Medicine, USA visits our college. Xiong Lab Poster Photo  
  2015-11-03 Paper accpeted - Congratulations to Yi-Zhi Wang, Jing-Jing Wang, et al!News
Wang YZ, Wang JJ, Huang Y, Liu F, Zeng WZ, Li Y, Xiong ZG, Zhu MX, Xu TL (2015) Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction. eLife.4: e05682.
 
  2015-10-26 Academic activity - Prof. Israel Sekler, the Chairman of Department of Physiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel, visited our lab. Poster photo1 2 3 4  
  2015-10-22

Happy Hour - Congratulations to Yi-Ming Jiang, Xing-Lei Song! They winned the Best Speakers in Journal Club 2015 of our department. Xing-Lei also obtained the Award of Best Host! Photo1 2

 
  2015-09-29 Paper accpeted - Congratulations to Zhong Peng, Wei-Guang Li, et al!
News in SJTU School of Medicine
Peng Z, Li WG, Huang C, Jiang YM, Wang X, Zhu MX, Cheng X*, Xu TL* (2015) ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand. Cell Reports, 13(2):387-398.
 
  2015-09-20 Academic activity - Lab members attended the 6th FAONS Congress and the 11th Biennial Conference of CNS in Jiaxing, Zhejiang. About Conference Photo  
  2015-09-15 Paper accpeted - Congratulations to Wei-Zheng Zeng, Di-Shi Liu, et al!
News in SJTU School of Medicine
Zeng WZ, Liu DS, Liu L, She L, Wu LJ*, Xu TL* (2015) Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling. Scientific Reports. 5:14125.
 
  2015-09-05 Academic activity - Lab members attended the Neuroscience Symposium of the Yangtze Delta in Nanking, Jiangsu. About Meeting  
  2015-08-28 Happy Hour - Congratulations to Ming-Gang Liu, Chen Huang & Di-Shi Liu!They winned the supports of National Natural Science Foundation of China!  
  2015-08-07 Happy Hour - Congratulations to Dr. Wei-Guang Li!He winned the Young Scientist Award of Shanghai Society for Neuroscience and "Kowloon Medical Young Talents Award 2015 " nomination of SHSMUPhoto1 2 3  
  2015-07-10 Academic activity - Dr. Xianping Dong from Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University (former students of our lab) visits our college. Poster Dong Lab  
  2015-07-09 Academic activity - Dr. Yunqing Li, director of Liang Qiuju Brain Research Center of Fourth Military Medical University (FMMU) visits our college. Poster Photo1 2 3  
  2015-07-04 Academic activity - Mid-project review meeting of major project supported by State Key Development Program for Basic Research of China (973)
News1 2 Photo1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
 
  2015-06-26 Academic activity - Lab members attended the 5th International Ion Channel Conference (IICC) in Luzhou, Sichuan. IICC Photo12 3  
  2015-06-25 Academic activity - Dr.Jianguo Gu from University of Alabama at Birmingham (UAB) vists our lab. Poster Gu Lab  
  2015-06-21 Academic activity - Lab Members attended Gordon Research Conference (GRC): Modulation of Neural Circuits & Behavior in Hongkong. GRC Photo1 2  
  2015-06-04 Academic activity - Dr. Xiangming Zha from University of South Alabama visits our lab. Poster Zha Lab  
  2015-05-25 Academic activity - Congratulations to Hu-Song Li, Jing-Jing Wang! They winned the 2nd prize and outstanding award for the oral and poster presentations respectively in the Doctoral Forum 2015 of Collaborative Innovation Center for Brain Science in Fudan University! News Photo1 2 3  
  2015-05-08 Academic activity - Dr. Zhi-Ping Pang from Child Health Institute of New Jersey visits our lab. Pang Lab Photo  
  2015-04-09 Academic activity - Dr. You-sheng Shu from State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University visits our college. Photo  
  2015-04-09 Academic activity - Dr. Jun Ding from Stanford University School of Medicine visits our college. Poster Photo  
  2015-04-08 Academic activity - Dr. Xiao Xiao from Department of Molecular Biophysics and Biochemsitry, Yale University visits our college.Poster  
  2015-03-19 Academic activity - Dr. Lei Chen from Vollum Institute, Oregon Health Science University visits our college. Poster Photo Reference1 2 3  
  2015-03-17 Happy Hour - Congratulations to Ming-Gang Liu!He winned the support of Eastern Scholar at Shanghai Institutions of Higher Learning!  
  2015-03-12 Academic activity - Dr. Neng Gong from Institute of Neuroscience, Chinese Academy of Sciences (former students of our lab) visits our college. Photo Reference Nature comments  
  2015-02-19 Happy Hour - Wish everyone happy in the Chinese lunar year of sheep!  
  2014-12-19 Happy Hour - Congratulations to Yi-Zhi Wang!He successfully finished his post-doctoral research!  
  2014-12-17 Happy Hour - Congratulations to Dr. Wei-Guang Li and Di-Shi Liu!They winned the Outstanding Postdoctoral Award of Shanghai Jiaotong University School of Medicine!  
  2014-12-17 Academic activity - Dr. Yi-Zhi Wang gave a scientific report about the mechanism underlies the regulation effect of acid-sensing ion channel on neuronal death in Shanghai Jiaotong University School of Medicine.  
  2014-12-10 Academic activity - Congratulations to Yi-Ming Jiang, Jing-Jing Wang and Hu-Song Li! They winned the 1st, 2nd and 3rd prizes respectively for the top presentations in Annual Progress Report of Neuroscience Program in Shanghai Jiao-Tong University School of Medicine!
Photo1 2 3 4 5 6 7 8 9 10 11 12
 
  2014-12-01 Happy Hour - Welcome to the 2014 rotation students  
  2014-11-27 Happy Hour - Welcome to the 2014 RBL students  
  2014-11-22 Academic activity - 2014 Annual Retreat for Department of Anatomy, Histology and Embryology. Photo  
  2014-10-24 Academic activity - Prof. Tian-Le Xu attended 24th Countrywide Member Congress of Chinese Physiological Society and gave a scientific report about the acid-sensing ion channel. Meeting website  
  2014-10-16 Academic activity - Prof. Tian-Le Xu and Prof. Yong Li attened the final evaluation meeting of the Major Research Plan of the National Natural Science Foundation of China "Structural basis, regulation and function of membrane trafficking of key sensory protein in neuronal signaling". Photo  
  2014-09-12 Academic activity - Prof. Tian-Le Xu and lab members attended Neuroscience Symposium of Yangtze Delta 2014 at Hangzhou, Zhejiang.  
  2014-08-02 Academic activity - Prof. Tian-Le Xu and Dr.Yi-Zhi Wang attended International Biophysics Congress - IUPAB 2014 at Brisbane, Australia IUPAB Conference Photo1 2  
  2014-07-10 Prof. Israel Sekler, the chairman of department of physiology, Ben-Gurion University, Israel, visited our lab and discussed constructively about the future research collaboration on mitochondrial ion channels. Sekler Lab  
  2014-06-23 Academic activity - Dr. Xiangming Zha from University of South Alabama visits our lab. Poster Zha Lab  
  2014-05-29 Happy Hour - Congratulations to Liu Di-Shi!He successfully finished his post-doctoral research! Photo of postdoctoral retreat  
  2014-04-28 Happy Hour - Congratulations to Zhong Peng on M.S. graduation!Photo1 2 3  
  2014-04-26 Academic activity - Initiating meeting of major project supported by State Key Development Program for Basic Research of China (973): Photo1 2 3 4 5 6 7 8 9 10 11 12 13 14 15  
  2014-04-25 Academic activity - Dr. Zhi-Ping Pang from Child Health Institute of New Jersey visits our lab. Pang Lab Reference1 2 3  
  2014-03-27 Academic activity - Dr. Jun Ding from Stanford University School of Medicine visits our lab. Ding Lab Reference1 2 3  
  2014-03-17 Academic activity - Ting-ting Hou from Cheng He-Ping's Lab,Institute of Molecular Medicine,Peking University, visits our lab.Cheng He-Ping's Lab Reference1 2 3  
  2014-03-14 Academic activity - Dr.Xiap-Ping Tong from UCLA visits our college. Poster Reference1 2  
  2014-01-30 Happy Hour - Wish everyone happy in the Chinese lunar year of horse!  
     
 

Selected Publications

 
 
  1. Li WG, Liu MG, Deng S, Liu YM, Shang L, Ding J, Hsu TT, Jiang Q, Li Y, Li F, Zhu MX, Xu TL (2016) ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion. Nature Communications, 7: 13770.

  2. Wang YZ, Wang JJ, Huang Y, Liu F, Zeng WZ, Li Y, Xiong ZG, Zhu MX, Xu TL (2015) Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction. eLife.4: e05682.

  3. Peng Z, Li WG, Huang C, Jiang YM, Wang X, Zhu MX, Cheng X, Xu TL (2015) ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand. Cell Reports, 13(2):387-398.

  4. Wang YZ, Zeng WZ, Xiao X, Huang Y, Song XL, Yu Z, Tang D, Dong XP, Zhu MX and Xu TL (2013) Intracellular ASIC1a regulates mitochondrial permeability transition-dependent neuronal death. Cell Death and Differentiation, 20, 1359-1369.

  5. Zeng WZ, Liu DS, Duan B, Song XL, Wang X, Wei D, Jiang W, Zhu MX, Li Y, Xu TL (2013) Molecular mechanism of constitutive endocytosis of acid-sensing ion channel 1a and its protective function in acidosis-induced neuronal death. Journal of Neuroscience, 33(16):7066-7078.

  6. Wang X, Li WG, Yu Y, Xiao X, Cheng J, Zeng WZ, Peng Z, Xi Zhu MX, Xu TL (2013) Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligand sensing domain of ASIC3 channel. Journal of Neuroscience, 33(10):4265-4279.

  7. Duan B, Liu DS, Huang Y, Zeng WZ, Wang X, Yu H, Zhu MX, Chen ZY, Xu TL (2012) PI3-kinase/Akt pathway-regulated membrane insertion of Acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity. Journal of Neuroscience, 32(18):6351-6363.

  8. Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, Zhu MX, Xiong ZG, Xu TL (2011) Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. Journal of Neuroscience, 31: 2101-2112.

  9. Yu Y, Chen Z, Li WG, Cao H, Feng EG, Yu F, Liu H, Jiang H, Xu TL (2010) A non-proton ligand sensor in the acid-sensing ion channel. Neuron, 68: 61-72.

  10. Gong N, Li Y, Cai GQ, Niu RF, Fang Q, Wu K, Chen Z, Lin LN, Xu L, Fei J, Xu TL (2009) GABA transporter-1 activity modulates hippocampal theta oscillation and theta burst stimulation-induced long-term potentiation. Journal of Neuroscience, 29: 15836-15845.

  11. Duan B, Wu LJ, Yu YQ, Ding Y, Jing L, Xu L, Chen J, Xu TL (2007) Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. Journal of Neuroscience, 27:11139-11148.

  12. Gao J, Duan B, Wang DG, Deng XH, Zhang GY, Xu L, Xu TL (2005) Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron, 48: 635-646.
 
   
 
 
 

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Tel: 86-21-34696291 Fax: 86-21-64453296 Email: jqin@@shsmu.edu.cn

 
   
     

 

 
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