Tian-Le Xu


Dr. Tian-Le Xu is chair of the Department of Anatomy, Histology and Embryology, and head of Laboratory of Neuronal Signaling at Shanghai Jiao Tong University School of Medicine. His current research focuses on neuronal signaling and related neural disorders with an emphasize on the role of acid-sensing ion channels in these processes. He is serving as editorial board member for the following journals: Molecular Pain, ACS Chemical Neuroscience, Frontiers in Pharmacology of Ion Channel and Channelopathies, Neuroscience Bulletin and Journal of Neurogenetics.


Research Interests

All brain functions depend on signal processing within and between neuronal cells. Understanding neuronal signaling is fundamental to determining how neurons communicate, integrate and store information. Furthermore, aberrant neuronal signaling is closely associated with neural dysfunctions and major brain disorders. Signaling proteins, in particular, neuronal membrane ion channels and receptors can therefore be therapeutic targets for neural diseases. My colleagues and I are interested in the regulation of neuronal signaling by ion channels and receptors with an emphasize on the role of acid-sensing ion channels (ASICs) in these processes.

Lab News

  2017-07-27 Paper published - Congratulations to Yi-Ming Jiang, Chen Huang, et al!
Jiang YM#, Huang C#, Peng Z, Han SL, Li WG, Zhu MX, Xu TL* (2017) Acidosis counteracts itch tachyphylaxis to consecutive pruritogen exposure dependent on acid-sensing ion channel 3. Molecular Pain, Jan-Dec; 13: 1744806917721114.
  2017-07-06 Academic activity - Professor Ming-Hu Han from Department of Neuroscience, Icahn School of Medicine at Mount Sinai, USA visits our department, and give us a wonderful lecture named "Resilience Neuroscience: from the Preclinical Model to the Patient". Poster Photo1 2 3 4 Han Lab  
  2017-06-28 Academic activity - Professor Stephan Alexander Pless from University of Copenhagen, Denmark visits our department, and give us a wonderful lecture named "New tools to study the molecular function and pharmacology of ion channels". Poster Photo1 2 3 Pless Lab  
  2017-06-23 Academic activity - Dr.Xu and our lab members attended the 6th International Ion Channel Conference(IICC), 2017 in Qingdao, Shandong. About Meeting  

Happy Hour - Congratulations to Hu-Song Li! He won the national scholarship this year!

  2017-06-09 Academic activity - Congratulations to our Ph.D. students for their wonderful talks and fantastic works presented in our progress report!  
  2017-05-15 Academic activity - Dr.Xu attended and presided over the Cold Spring Habor Asia (CSHA) Conference: Membrane Proteins: Structure & Function, 2017 in Soochow, Jiangsu. About Meeting  
  2017-05-08 Academic activity - Lab members attended Cold Spring Habor Asia (CSHA) Conference: Francis Crick Symposium Transforming Neurosciences: Questions & Experiments, 2017 in Soochow, Jiangsu. About Meeting  
  2017-04-19 Academic activity - Lab members attended ITNCR (Innovative Technologies on Neural Circuit Research) Meeting (virus tracing, imaging & function), 2017 in Wuhan, Hubei. About Meeting  
  2017-03-04 Academic activity - Annual review meeting of major project supported by State Key Development Program for Basic Research of China (973)
Photo1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27
  2016-12-16 Academic activity - Prof. Guo-Hui Su, academician of Chinese Academy of Sciences (CAS),dean of Guangdong-Hong Kong-Macao Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou, visits our college. Poster News Photo  
  2016-12-08 Paper published - Congratulations to Wei-Guang Li, Ming-Gang Liu, Shi-Ning Deng, et al!
Li WG#, Liu MG#, Deng S#, Liu YM, Shang L, Ding J, Hsu TT, Jiang Q, Li Y, Li F*, Zhu MX*, Xu TL* (2016) ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion. Nature Communications, 7: 13770.
  2016-12-07 Academic activity - Dr. Yi-Zhi Wang from the Ken and Ruth Davee Department of Neurology, Northwestern University (former students of our lab) visits our lab.  
  2016-11-23 Academic activity - SJTU-ZJU-STU Joint Symposium for Neuroscience was held in our department!Congratulations to our lab members for their best performance! Poster  
  2016-11-13 Academic activity - Dr. Qin Hu attended in The 1st Gusu Translational Stroke Research Summit & the 4th International Symposium on Tolerance and Conditioning: "30 Years of Science and Hope" in Soochow. About Meeting Photo  
  2016-10-28 Academic activity - Lab Members attended Annual Meeting of "Neural Circuit Basis of Emotion and Memory" (Supported by Major Research Plan of the National Natural Science Foundation of China), 2016 in Shenzhen, Guangdong. About Meeting  
  2016-10-25 Happy Hour - Congratulations to Jing-Jing Wang on Ph.D. graduation!Photo1 2 3  
  2016-09-25 Academic activity - Dr.Wei-Guang Li attended 2016 International Conference of Physiological Sciences (ICPS2016) in Peking, and gave a scientific presentation named "ASIC1a regulates insular LTD and is required for extinction of CTA". About Meeting Photo  
  2016-09-10 Happy Hour - Happy Teacher's Day to Prof. Xu and all the young teachers in our lab! Lab Photo  
  2016-09-09 Academic activity - Ivana Savic, Ph.D. student from Department of Physiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel, visited our lab and colaborated with us on the NSFC-ISF project. Photo1 2 3 4  
  2016-09-07 Academic activity - Congratulations to Yan-Jiao Wu, Fan Liu, Xing-Lei Song and Xin-Yu Su!They winned Best Presentors on their Annual Reports of the Neuroscience Division, Shanghai Jiao Tong University School of Medicine this year!Photo1 2 3 4 5 6 7 8 9 10 11  
  2016-07-25 Academic activity - Hu-Song Li attented Symposium for Chinese Neuroscientists Worldwide 2016 (SCNW) in Hefei, Anhui. About Meeting Photo  
  2016-06-24 Academic activity - Dr. Qin Hu attended 2nd Annual Scientific Session of Chinese Stroke Association (TISC 2016) in Beijing. About Meeting  
  2016-06-08 Academic activity - Dr. Wen Zhang (former students of our lab) from National Institute on Drug Abuse Intramural Research Program, National Institutes of Health (NIH), USA visits our college. Poster  

Selected Publications

  1. Li WG, Liu MG, Deng S, Liu YM, Shang L, Ding J, Hsu TT, Jiang Q, Li Y, Li F, Zhu MX, Xu TL (2016) ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion. Nature Communications, 7: 13770.

  2. Wang YZ, Wang JJ, Huang Y, Liu F, Zeng WZ, Li Y, Xiong ZG, Zhu MX, Xu TL (2015) Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction. eLife.4: e05682.

  3. Peng Z, Li WG, Huang C, Jiang YM, Wang X, Zhu MX, Cheng X, Xu TL (2015) ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand. Cell Reports, 13(2):387-398.

  4. Wang YZ, Zeng WZ, Xiao X, Huang Y, Song XL, Yu Z, Tang D, Dong XP, Zhu MX and Xu TL (2013) Intracellular ASIC1a regulates mitochondrial permeability transition-dependent neuronal death. Cell Death and Differentiation, 20, 1359-1369.

  5. Zeng WZ, Liu DS, Duan B, Song XL, Wang X, Wei D, Jiang W, Zhu MX, Li Y, Xu TL (2013) Molecular mechanism of constitutive endocytosis of acid-sensing ion channel 1a and its protective function in acidosis-induced neuronal death. Journal of Neuroscience, 33(16):7066-7078.

  6. Wang X, Li WG, Yu Y, Xiao X, Cheng J, Zeng WZ, Peng Z, Xi Zhu MX, Xu TL (2013) Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligand sensing domain of ASIC3 channel. Journal of Neuroscience, 33(10):4265-4279.

  7. Duan B, Liu DS, Huang Y, Zeng WZ, Wang X, Yu H, Zhu MX, Chen ZY, Xu TL (2012) PI3-kinase/Akt pathway-regulated membrane insertion of Acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity. Journal of Neuroscience, 32(18):6351-6363.

  8. Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, Zhu MX, Xiong ZG, Xu TL (2011) Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. Journal of Neuroscience, 31: 2101-2112.

  9. Yu Y, Chen Z, Li WG, Cao H, Feng EG, Yu F, Liu H, Jiang H, Xu TL (2010) A non-proton ligand sensor in the acid-sensing ion channel. Neuron, 68: 61-72.

  10. Gong N, Li Y, Cai GQ, Niu RF, Fang Q, Wu K, Chen Z, Lin LN, Xu L, Fei J, Xu TL (2009) GABA transporter-1 activity modulates hippocampal theta oscillation and theta burst stimulation-induced long-term potentiation. Journal of Neuroscience, 29: 15836-15845.

  11. Duan B, Wu LJ, Yu YQ, Ding Y, Jing L, Xu L, Chen J, Xu TL (2007) Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. Journal of Neuroscience, 27:11139-11148.

  12. Gao J, Duan B, Wang DG, Deng XH, Zhang GY, Xu L, Xu TL (2005) Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron, 48: 635-646.

280 Chongqing Road Shanghai 200025
Tel: 86-21-34696291 Fax: 86-21-64453296 Email: jqin@@shsmu.edu.cn



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